Cardiovascular aims
The cardiovascular theme aims to prevent premature death and reduce the severity of illness due to heart diseases through: early diagnosis; improving the ways to predict which patients are at high risk; and personalising treatments so they are more effective for the individual. We will achieve this by focusing on our two existing areas of strength:
Cardiovascular genetics and biomarkers
Novel cardiovascular interventions
We aim to:
- Translate our discoveries about the genetic basis of coronary artery disease (CAD) towards improved understanding, prediction, prevention and treatment
- Extend the genomic discovery platform to other cardiovascular diseases, including diseases of the aortic valve and aorta, and rare coronary phenotypes, including spontaneous coronary artery dissection (SCAD)
- Identify novel plasma biomarkers for diastolic heart failure and CAD that will inform personalised prevention and treatment strategies
- Address remaining challenges in percutaneous intervention for ventricular fibrillation to reduce the frequency of sudden cardiac death (SCD)
- Evaluate the efficacy of new organ protection interventions, such as stents, during cardiac surgery and following a myocardial infarction (heart attack), and take these interventions from pre-clinical development into first-in-man trials
- Investigate the mechanisms underlying changes in blood flow during stroke, and evaluate interventions that target these processes to improve outcomes following stroke
For more information on our current research, view our case studies: