Investigating the possible link between habitual diet, physical activity, sleeping patterns, obesity status and age with gut bacterial composition, gut barrier function, metabolic endotoxemia, systemic inflammation and glycemic control.
Principle Invesitigators: Dr. Carl Hulston, Dr. Oonagh Markey, Malvina Begall
In the UK, 25% of the adults are affected by metabolic syndrome (NHS, 2016). Metabolic syndrome is a cluster of different conditions including: hyperglycaemia, insulin resistance hypertriglyceridemia, dyslipidaemia and hypertension. Such individuals also have increased risk of developing type 2 diabetes and cardiovascular disease. The factors contributing to the development of metabolic syndrome are potentially numerous and understudied in humans.
It has been suggested that changes in the composition of the gut microbiota may drive insulin resistance and type 2 diabetes through a mechanism that is linked to increased gut permeability and the development of metabolic endotoxemia and inflammation.
The aim of this project is to investigate the relationship between different physiological and behavioural/ lifestyle variables (such as habitual diet, physical activity, sleeping patterns, obesity status and age etc.) and measures of gut bacterial composition, gut barrier function, metabolic endotoxemia, systemic inflammation and glycemic control.
For more information about the study contact: firstname.lastname@example.org or phone 01509 226445
Study Poster: Recruitment Poster (R18-P206)
Patient Information Sheet: The Gut Microbiota Study- Participant information sheet