The aim of the precision medicine theme is to enable the most appropriate treatment decisions to be made for the individual patient; to maximise their well-being and ability to manage their conditions; and to minimise side effects. We will analyse information gathered from genomics alongside other data within the 3 themes to optimise therapeutic responses. This will allow us to develop tailored disease management programmes.
We aim to:
- Optimise the latest methods and technologies used to identify important molecules for analysing human samples such as plasma, urine and sputum
- Develop methods for measuring medicine-taking behaviours in patients in order to assess the impact of compliance with courses of medication on heart failure, asthma and diabetes outcomes
- Assess whether analysing samples of plasma and urine for important biomarkers improves the accuracy of predicting risk in acutely breathless patients and develop mathematical models to put patients into different subgroups based on these biomarkers
- Assess the role of products of the microorganisms in our bodies and imbalances in ‘good’ and ‘bad’ microorganisms that may impact on inflammation, immunity and metabolism on outcome in patients with cardio-respiratory-metabolic disease. This may lead to targeted diet or exercise regimes
- Investigate the effect of tailored exercise regimes on the structure of the heart and changes to the chemicals and hormones released by it in diabetes and Chronic Obstructive Pulmonary Disease (COPD). The way this response differs among different ethnicities will be investigated and programmes will be devised to target high risk groups (such as members of the South Asian population and patients with heart failure)